Antidepressants are a broad range of drugs that treat depression by altering brain chemicals to reduce restlessness, anxiety, and sleep disorders. These drugs work by altering the functioning of brain regions that are controlled by neurotransmitters, which transfer messages between brain cells. Antidepressants are also used to improve mental state or mood. Antidepressants have been broadly used in the treatment of many chronic pain syndromes, such as nerve-related pain disorders (neuropathy). Common antidepressants prescribed by physicians include: citalopram (Celexa), fluoxetine (Prozac), sertraline (Zoloft), duloxetine (Cymbalta), and paroxetine (Paxil).
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