11 Primary Causes of Peripheral Neuropathy

Source: Mayo Clinic

Peripheral neuropathy occurs due to many underlying medical conditions. There are many occurrences where the cause is unknown, idiopathic. Diabetes mellitus is the common cause of peripheral neuropathy. The other primary causes of peripheral neuropathy include:


Some viral or bacterial infections such as shingles, Lyme disease, Epstein-Barr virus, hepatitis C, HIV, leprosy, and diphtheria can cause peripheral neuropathy.

Vitamin deficiency

Nerve health depends on B1, B3, B6, B12, folate, and vitamin E. Malnutrition from an unbalanced diet can cause damage to peripheral nerves.


The toxic effect on the nerve tissue and alcohol abuse can create an unbalanced, unhealthy diet leading to vitamin deficiencies. They often describe a burning and tingling sensation in their feet.

Autoimmune diseases

Diseases in which your immune system attacks your own tissue include lupus, rheumatoid arthritis, Sjogren’s syndrome, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, and necrotizing vasculitis.

Inherited disorders

These heredity types include Charcot-Marie-Tooth and amyloid polyneuropathy diseases can cause peripheral neuropathy.

Trauma or pressure on the affected nerve

Trauma from a motor vehicle accident, sport injury, or falls damage or sever peripheral nerves. Repetitive motion from an activity or occupation such as typing or using crutches can contribute to pressure on nerves resulting in nerve damage. Tight plaster casts can also put pressure on nerves.


Growths and both cancerous and noncancerous tumors can develop or apply pressure on the nerve. Paraneoplastic syndrome, a cancer related immune response that attacks your body, can also cause pressure to nerves and impair function.

Exposure to toxins

Such as heavy metals, chemicals, gold compounds, lead, arsenic, mercury, organophosphate pesticides.

Certain Medications

Cancer therapy, HIV, antibiotics, and statin medications can cause damage to peripheral nerves.


Peripheral neuropathy can occur in lymphoma, osteosclerotic myeloma, and multiple myeloma.

Other diseases

Such as liver disease, hypothyroidism, or connective tissue disorders. Kidney disease causes peripheral nerve damage due to the imbalance of chemicals, salt, fluids, and waste products that accumulate in the body.

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