Medications for Treating Multiple Sclerosis Pain Symptoms


Multiple sclerosis is a disease that impacts the nervous system, and it can cause people who live with it a great deal of pain. Doctors typically prescribe one or more, of the following seven medications, to reduce MS pain. You’ll notice that many of these medications are used to treat MS symptoms that have seemingly little to do with their original purpose. Since much of the pain caused by MS is a result of various nerve problems and there are few medications developed specifically to handle them, medications are often prescribed " off-label" for MS treatment. Many of these medications have multiple uses in the treatment of common MS symptoms, but all of them are used to treat some type of MS pain.


This medication is most often used for individuals with epilepsy to control seizures. It’s an anticonvulsant, but it does an exceptional job treating MS pain sensations caused by demyelination of the sensory pathways.


This medication is a tricyclic antidepressant used for treating clinical depression, but it is often used to treat the annoying and often painful pins and needles sensations in the arms and legs that are a symptom of MS.


This medication was created to treat seizures and nerve pain. It is usually used in individuals with multiple sclerosis to eliminate shock-like nerve pain, such as the trigeminal nerve pain that occur in the face.


This is another tricyclic antidepressant with off-label nerve pain resolution qualities. The tingling, pins and needles, or burning pain it treats is often referred to as paresthesia.


This medication falls into a class of drugs called benzodiazepines. They are used to suppress central nervous system (CNS) activity, slowing it to relieve pain, spasticity, and tremor that are common side effects of MS.


This is another anti-epileptic medication that was created to treat seizures. For MS, it is often prescribed to help reduce pain due to spasticity, as well as pain from MS lesions.

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